Opium Poisoning
Source: opium — dried latex obtained from Papaver somniferum.
Active principles: Morphine, Codeine, Thebaine.
Mechanism
- CNS depressant; acts mainly on opioid receptors; produces respiratory depression.
Clinical Features — Classical Triad
- Coma — deep unconsciousness.
- Respiratory depression — slow, shallow respiration; respiratory failure in severe cases.
- Pinpoint pupils (Miosis) — most characteristic sign.
Other features: cyanosis of face; slow weak pulse; subnormal temperature; cold clammy skin. Terminal stage: respiratory arrest, death.
Postmortem Findings
- Congestion of organs, pulmonary edema, cyanosis, froth at mouth and nostrils.
Treatment
- ABC management — Airway, Breathing, Circulation.
- Specific antidote — Naloxone (drug of choice).
- Supportive — oxygen, ventilatory support, monitoring.