Definition
- Aldosterone is the major mineralocorticoid in humans, secreted by the zona glomerulosa of the adrenal cortex.
- Its main function is to increase Na+ and water reabsorption and promote K+ and H+ excretion from the kidney.
Regulation of Aldosterone Secretion
Angiotensin-Aldosterone
- Aldosterone secretion is regulated by three stimuli: angiotensin II, ACTH, and plasma K+ concentration.
The renin-angiotensin-aldosterone cascade: