Quick Orientation
Section
Definition
- Objective
- Understand the core idea
- Keywords
- animal sterol, 140 g
Sites of Cholesterol Synthesis
- Objective
- Follow the sequence and key control points
- Keywords
- 1 g cholesterol, liver (50%), intestine (15%)
Pathway of Cholesterol Biosynthesis
- Objective
- Follow the sequence and key control points
- Keywords
- acetyl CoA, 14C, cytosol and microsomal fractions
Energetics of Cholesterol Synthesis
- Objective
- Follow the sequence and key control points
- Keywords
- 1 mole cholesterol, 18 moles acetyl CoA, 36 moles ATP
Regulation of Cholesterol Synthesis
- Objective
- Follow the sequence and key control points
- Keywords
- rate-limiting enzyme HMG CoA reductase, endoplasmic reticulum
Clinical Correlation
- Objective
- Connect the mechanism to clinical findings
- Keywords
- essential to life