Quick Orientation
Section
Definition
- Objective
- Understand the core idea
- Keywords
- Collagen
Distribution and Types
- Objective
- Separate the major categories
- Keywords
- 19 genetically distinct types, type I, type II
Structure
- Objective
- See how the components fit together
- Keywords
- Type I mature collagen, 1.4 nm in diameter and 300 nm long, (Gly-X-Y)n
Biosynthesis
- Objective
- Follow the sequence and key control points
- Keywords
- fibroblasts, preprocollagen, procollagen
Clinical Correlation
- Objective
- Connect the mechanism to clinical findings
- Keywords
- Scurvy, Lathyrism, Kesari dal (Lathyrus sativus)
Definition
Collagen: the most abundant protein in mammals (about one-third of total body protein), the predominant structural protein of connective tissue.
- A triple-helical protein forming 90% of bone organic matrix, 85% of tendon, 70% of skin and 4% of liver.