Jaundice: biochemical basis and laboratory differentiation

Quick Orientation

Section	Objective	Keywords
Definition	Understand the core idea	Jaundice (icterus), hyperbilirubinemia
Classification of Jaundice	Separate the major categories	hemolytic, hepatic, obstructive
Neonatal-Physiologic Jaundice	Learn the main facts and relationships	Neonatal physiologic jaundice, UDP-glucuronyltransferase, UDP-glucuronic acid
Phototherapy	Learn the main facts and relationships	Phototherapy, 420 to 470 nm, photoisomerization
Clinical Correlation	Connect the mechanism to clinical findings	Kernicterus, phenobarbital, Crigler-Najjar syndrome type I

Section

Definition

Objective: Understand the core idea
Keywords: Jaundice (icterus), hyperbilirubinemia

Classification of Jaundice

Objective: Separate the major categories
Keywords: hemolytic, hepatic, obstructive

Neonatal-Physiologic Jaundice

Objective: Learn the main facts and relationships
Keywords: Neonatal physiologic jaundice, UDP-glucuronyltransferase, UDP-glucuronic acid

Phototherapy

Objective: Learn the main facts and relationships
Keywords: Phototherapy, 420 to 470 nm, photoisomerization

Clinical Correlation

Objective: Connect the mechanism to clinical findings
Keywords: Kernicterus, phenobarbital, Crigler-Najjar syndrome type I

Definition

Jaundice (icterus): clinical condition of yellow discoloration of the sclerae and skin due to bilirubin deposition from elevated serum bilirubin (hyperbilirubinemia).