Biochemistry · Clinical Biochemistry and Laboratory Medicine

Plasma proteins and immunoglobulins in clinical disease

6 min read

Quick Orientation

Section

Definition

Objective
Understand the core idea
Keywords
Plasma proteins, 6 to 8 g/dL, albumin, α1, α2, β and γ-globulins

Separation of Plasma Proteins

Objective
Learn the main facts and relationships
Keywords
albumin 3.5 to 5.0 g/dL, 2.5 to 3.5 g/dL, A/G ratio 1.2 to 1.5:1

Albumin

Objective
Learn the main facts and relationships
Keywords
Albumin, 60%, exclusively by the liver

Globulins

Objective
Learn the main facts and relationships
Keywords
Globulins

Acute Phase Proteins

Objective
Learn the main facts and relationships
Keywords
Acute phase proteins, negative acute phase reactants, C-reactive protein (CRP)

Clinical Correlation

Objective
Connect the mechanism to clinical findings
Keywords
Multiple myeloma, M band, Bence Jones proteins

Definition

Plasma proteins are the protein fraction of plasma, total concentration 6 to 8 g/dL (albumin, globulins, fibrinogen).