Quick Orientation
Section
Definition
- Objective
- Understand the core idea
- Keywords
- Detoxification (biotransformation), oxidation, reduction, hydrolysis, conjugation
Site of Detoxification
- Objective
- Learn the main facts and relationships
- Keywords
- liver, kidney
Mechanism: Phase I and Phase II Reactions
- Objective
- Follow the sequence and key control points
- Keywords
- Phase I, Phase II, oxidation followed by conjugation
Phase I Reactions: Oxidation, Reduction and Hydrolysis
- Objective
- Follow the sequence and key control points
- Keywords
- Oxidation, Cytochrome P450, 450 nm
Phase II Reactions: Conjugation
- Objective
- Follow the sequence and key control points
- Keywords
- Conjugation, 8 conjugating agents, Glucuronic acid
Clinical Correlation
- Objective
- Connect the mechanism to clinical findings
- Keywords
- Detoxification is a misnomer, Enzyme induction, Heavy metal poisoning treated with BAL