Biochemistry · Lipid Metabolism

HDL and reverse cholesterol transport

3 min read

Quick Orientation

Section

Definition

Objective
Understand the core idea
Keywords
High density lipoprotein (HDL), reverse cholesterol transport (RCT)

Formation and Composition of Nascent HDL

Objective
See how the components fit together
Keywords
discoidal, lecithin, A, CII, E

Reverse Cholesterol Transport Pathway

Objective
Follow the sequence and key control points
Keywords
lecithin-cholesterol acyltransferase (LCAT), Apoprotein A, spherical HDL

Hepatic Uptake and Fate of Cholesteryl Ester

Objective
Learn the main facts and relationships
Keywords
SR-BI, CETP, bile acid

Clinical Correlation

Objective
Connect the mechanism to clinical findings
Keywords
Cardioprotective role, antioxidant, paraoxonase 1 (PON1)

Definition

High density lipoprotein (HDL), the "good cholesterol", is synthesized in the liver as nascent discoidal particles and drives reverse cholesterol transport (RCT).