Quick Orientation
Section
Definition
- Objective
- Understand the core idea
- Keywords
- High density lipoprotein (HDL), reverse cholesterol transport (RCT)
Formation and Composition of Nascent HDL
- Objective
- See how the components fit together
- Keywords
- discoidal, lecithin, A, CII, E
Reverse Cholesterol Transport Pathway
- Objective
- Follow the sequence and key control points
- Keywords
- lecithin-cholesterol acyltransferase (LCAT), Apoprotein A, spherical HDL
Hepatic Uptake and Fate of Cholesteryl Ester
- Objective
- Learn the main facts and relationships
- Keywords
- SR-BI, CETP, bile acid
Clinical Correlation
- Objective
- Connect the mechanism to clinical findings
- Keywords
- Cardioprotective role, antioxidant, paraoxonase 1 (PON1)
Definition
High density lipoprotein (HDL), the "good cholesterol", is synthesized in the liver as nascent discoidal particles and drives reverse cholesterol transport (RCT).