Quick Orientation
Section
Definition
- Objective
- Understand the core idea
- Keywords
- Folic acid, vitamin B12 (cobalamin), megaloblastic anemia
Chemistry and Active Forms
- Objective
- Learn the main facts and relationships
- Keywords
- pteroylglutamic acid (PGA), dihydrofolate reductase, corrin ring
Absorption, Transport and Storage
- Objective
- Learn the main facts and relationships
- Keywords
- Folate, folate conjugase, N5-methyl THF
One-Carbon Metabolism and Biochemical Functions
- Objective
- Follow the sequence and key control points
- Keywords
- THF, N5 and/or N10, two reactions in mammals
Folate-B12 Interrelationship: Methyl Trap Hypothesis
- Objective
- Learn the main facts and relationships
- Keywords
- N5-methyl THF, B12 deficiency, folate trap
Clinical Correlation
- Objective
- Connect the mechanism to clinical findings
- Keywords
- Megaloblastic anemia, macrocytic RBC, Pernicious anemia