Physiology · Reproductive Physiology

Circulatory and respiratory changes at birth

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Definition

  • At birth, cord clamping abolishes umbilical blood flow and triggers circulatory and respiratory changes that convert fetal circulation into the adult postnatal pattern.
  • Before birth, fetal lungs are functionally inactive and gas exchange occurs via the placenta; umbilical venous blood is only about 80% saturated with oxygen.

Fetal Circulation: Shunts and Oxygenation

  • Placenta functions as the fetal lungs; oxygenated blood reaches the fetus through the umbilical vein.
  • Three shunts bypass the fetal liver and lungs:
    • Ductus venosus: into inferior vena cava.
    • Foramen ovale: right atrium to left atrium.
    • Ductus arteriosus: pulmonary artery to aorta.

Fetal circulation, schematic diagram