Physiology · Reproductive Physiology

Parturition and role of oxytocin

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Definition

  • Parturition is vaginal delivery of the fetus at term, about 40 weeks from the last menstrual period (38 weeks from ovulation).
  • Delivery between the 28th and the completed 37th week of gestation defines a premature infant.

Preparation for Parturition

  • In the last weeks of pregnancy, rising estrogen increases myometrial connexin synthesis, forming gap junctions that coordinate myometrial contraction.
  • Estrogen also induces synthesis of oxytocin receptors in the myometrium, enhancing uterine smooth muscle contraction.
  • The cervix softens through enzymatic lysis of its collagen fibers; relaxin, secreted from the placenta and ovaries, facilitates cervical softening and dilation.

Stages of Labor