Quick Orientation
Section
Definition
- Objective
- Understand the core idea
- Keywords
- DNA replication, semiconservative, S-phase
Initiation and the Replication Fork
- Objective
- Learn the main facts and relationships
- Keywords
- origin of replication, dnaA, replication bubble
Mechanism of DNA Synthesis
- Objective
- Follow the sequence and key control points
- Keywords
- leading strand, lagging strand, Okazaki fragments
Replication in Eukaryotes
- Objective
- Learn the main facts and relationships
- Keywords
- DNA polymerase ε, DNA polymerase δ, PCNA
Cell Cycle and DNA Replication
- Objective
- Follow the sequence and key control points
- Keywords
- 500 to 1,000 DNA polymerases, DNA methylation, Cyclins
Clinical Correlation
- Objective
- Connect the mechanism to clinical findings
- Keywords
- Antibacterial gyrase inhibitors, Anticancer topoisomerase inhibitors, Antimetabolite anticancer drugs