Forensic Medicine · Toxicology — General Principles

Antidotes: Definition & Four Classes

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Definition

An antidote is a substance which counteracts, neutralizes, prevents, or diminishes the effects of a poison.

Classification of Antidotes

There are four classes: Physical, Chemical, Physiological, and Chelating agents.

1. Physical (Mechanical) Antidotes

Act by preventing absorption of the poison without chemically altering it.

  • Mechanism: adsorption, coating, dilution.
  • Examples: activated charcoal, milk, egg albumin.

2. Chemical Antidotes

Act by chemically reacting with the poison to form a harmless or less toxic compound.

PoisonChemical Antidote
ArsenicFerric hydroxide
CyanideSodium nitrite + Sodium thiosulphate
Heavy metalsChelating agents