Biochemistry · Carbohydrate Metabolism

Gluconeogenesis and its regulation

5 min read

Quick Orientation

Section

Definition

Objective
Understand the core idea
Keywords
Gluconeogenesis, liver, kidney

Reactions of Gluconeogenesis

Objective
Follow the sequence and key control points
Keywords
cytosol, reversed glycolysis, Stoichiometry

Substrates of Gluconeogenesis

Objective
Learn the main facts and relationships
Keywords
leucine and lysine, Glycerol, glycerokinase

Cori Cycle and Glucose-Alanine Cycle

Objective
Follow the sequence and key control points
Keywords
Cori cycle, lactate dehydrogenase, Glucose-alanine cycle

Regulation of Gluconeogenesis

Objective
Track activators, inhibitors and feedback
Keywords
glucagon, glucogenic amino acids, Glucagon

Clinical Correlation

Objective
Connect the mechanism to clinical findings
Keywords
Diabetes mellitus, Alcohol-induced hypoglycemia

Definition