Glycogen metabolism and hormonal regulation

Quick Orientation

Section	Objective	Keywords
Definition	Understand the core idea	Glycogen
Functions of Glycogen	Learn the main facts and relationships	Functions of Glycogen
Glycogenesis	Learn the main facts and relationships	Glycogenesis
Regulation of Glycogen Synthase and Phosphorylase	Track activators, inhibitors and feedback	glycogen synthase, glycogen phosphorylase, 'a'
Hormonal Regulation via cAMP	Track activators, inhibitors and feedback	cAMP, adenylate cyclase, Phosphodiesterase
Clinical Correlation	Connect the mechanism to clinical findings	Pompe's disease (glycogen storage disease type II), acid maltase (α-1,4-glucosidase)

Section

Definition

Objective: Understand the core idea
Keywords: Glycogen

Functions of Glycogen

Objective: Learn the main facts and relationships
Keywords: Functions of Glycogen

Glycogenesis

Objective: Learn the main facts and relationships
Keywords: Glycogenesis

Regulation of Glycogen Synthase and Phosphorylase

Objective: Track activators, inhibitors and feedback
Keywords: glycogen synthase, glycogen phosphorylase, 'a'

Hormonal Regulation via cAMP

Objective: Track activators, inhibitors and feedback
Keywords: cAMP, adenylate cyclase, Phosphodiesterase

Clinical Correlation

Objective: Connect the mechanism to clinical findings
Keywords: Pompe's disease (glycogen storage disease type II), acid maltase (α-1,4-glucosidase)

Definition

Glycogen is the storage form of glucose in animals, as starch is in plants; stored as cytosolic granules mainly in liver (6 to 8%) and muscle (1 to 2%).