Biochemistry · Carbohydrate Metabolism

TCA cycle: pathway, regulation and significance

5 min read

Quick Orientation

Section

Definition

Objective
Understand the core idea
Keywords
citric acid cycle, acetyl CoA, 65 to 70% of body ATP

Location of TCA Cycle

Objective
Follow the sequence and key control points
Keywords
mitochondrial matrix

Central Role of the Citric Acid Cycle

Objective
Follow the sequence and key control points
Keywords
final common oxidative pathway, amino acid, glucose and heme, amphibolic

Reactions of the Citric Acid Cycle

Objective
Follow the sequence and key control points
Keywords
pyruvate to acetyl CoA, acetyl CoA, oxaloacetate

Regulation of the Citric Acid Cycle

Objective
Follow the sequence and key control points
Keywords
ATP demand, ADP levels

Clinical Correlation

Objective
Connect the mechanism to clinical findings
Keywords
Fluoroacetate poisoning, fluorocitrate, aconitase

Definition