Quick Orientation
Section
Definition
- Objective
- Understand the core idea
- Keywords
- Pyruvate dehydrogenase complex (PDH), irreversible oxidative decarboxylation, acetyl CoA
Site, Structure and Cofactors
- Objective
- See how the components fit together
- Keywords
- only in mitochondria, cardiac muscle and kidney, five cofactors
Metabolic Significance of Pyruvate
- Objective
- Learn the main facts and relationships
- Keywords
- citric acid cycle, fatty acid synthesis, gluconeogenesis
Reactions of the PDH Complex
- Objective
- Follow the sequence and key control points
- Keywords
- Step 1, hydroxyethyl-TPP, Step 2
Regulation of PDH
- Objective
- Track activators, inhibitors and feedback
- Keywords
- end-product inhibition, phosphorylation and dephosphorylation, PDH phosphatase
Clinical Correlation
- Objective
- Connect the mechanism to clinical findings
- Keywords
- Arsenic poisoning (arsenite), thiol (-SH) groups of lipoic acid